Generic Tazorac cream (Tazret) contains the active ingredient Tazarotene that belongs to the group of retinoids derived from vitamin A. This is applied for the treatment of acne vulgaris and psoriasis (plaque form). Tazarotene cream (Tazret) is also used for the signs and symptoms (appearance and texture) of premature skin aging caused by overexposure to the sun (known as photoaging).
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Product name - Generic Tazorac Tazarotene cream 0.1% 15g
Tazret cream 0.01% and Tazret gel 0.05% 15g made by Glenmark
Qualitative and quantitative composition - Generic Tazarotene cream 0.1% contains 0.1% (1 mg/g) Tazarotene as the main component. Other ingredients are Butylhydroxyanisole (0.05%), Butylhydroxytoluene (0.05%), tromethamine, polysorbate 40, poloxamer 407, macrogol 400, hexylene glycol, disodium edetate, carbomer 974P, benzyl alcohol, ascorbic acid, and purified water.
Generic Tazarotene gel has concentration 0.05%.
Action mechanism - Tazarotene is a form of vitamin A. It primarily helps your skin remain inflammation free by keeping its pores unobstructed (in case of acne). Psoriasis is a type of chronic disease mediated by the abnormal immune response. It is marked by abnormal keratinocyte differentiation, hyperproliferation, and inflammation. The symptoms of Psoriasis may be due to the T lymphocyte infiltration at the affected site triggered by the inflammatory response and subsequent release of cytokines.
Tazarotene down-regulates these abnormal effects on keratinocyte while upregulating three genes with antiproliferative effects.
Tazarotene relieves psoriasis by reducing inflammation and maintaining cell growth at a normal rate. It seems to help against acne partly by keeping the pores unobstructed. You will begin to notice an improvement within 1 to 4 weeks from the start of treatment. However, it depends on the disorder to be treated and its severity.
Indication - Generic Tazorac Tazarotene is indicated for the treatment of psoriasis. It is used in the treatment of mild or moderate psoriasis plaques (the most common form of psoriasis) when less than 10% of the body area is affected. This is roughly equivalent to the surface of an arm.
Mode of administration - It is present in the cream or gel form and applied topically on the affected area. Apply a thin layer of tazarotene cream or gel once daily in the evening on affected areas only. The skin must be dry before applying the drug. If you also use emollient or moisturizing creams, apply them first (at least an hour before) and allow them to be absorbed into the skin before applying tazarotene cream or gel. It is sometimes prescribed for the treatment of acne.
Contraindication - It is not indicated for the treatment of suppurative or pustular psoriasis or psoriasis with an increased formation of scales (exfoliative psoriasis). It is also not used in scalp covered with hair, on the face, and wet areas covered with hair such as armpits.
If you are allergic (hypersensitive) to the active substance or any of the other components of the formulation, do not use this cream. Symptoms of allergic reactions may include asthma, breathing difficulties, breathing with audible whistling sounds or rapid breathing, swelling of the face, lips, tongue or other areas of the body. Other symptoms are hives, itching, and rash. Severe allergy can cause loss of consciousness, paleness, sweating, etc.
It is not recommended to use this medicine during pregnancy, lactation, or when pregnancy is planned.
Special cautions and warnings - The application of tazarotene in healthy, eczematous or inflamed skin can cause irritation. Do not apply tazarotene in more than 10% of the total body surface area. Avoid excessive exposure to UV rays (PUVA therapy, solarium, sun, or UVB therapy) during treatment. Coal tar shampoos should also be avoided.
Especially avoid contact with eyes, lips and mucous membranes. Wash with plenty of water if accidental contact is made. Wash your hands with soap and water after applying the gel or cream and remove the medicine from unaffected areas.
Retinoids can cause severe irritation on eczematous skin. If you have eczema, your doctor will monitor your condition while you use tazarotene.
Interaction - Avoid the simultaneous application of other products on the skin, if they have a strong dehydrating effect. It can interact with different vitamin A products, perming solutions for hair, medicated cleansers, shampoos, and soaps, astringents (perfumes, calamine), and other skin products containing lime or alcohol.
Side effects - A side effect is an undesirable response to a generic Tazorac when taken at normal doses, which may be mild and temporary. But sometimes severe and permanent effects are witnessed. At least 1% of people taking this medication have reported the following side effects. Many of these side effects can be taken care of and some can go away on their own with time. These are:
A tingling or cooking feeling after application
Redness or scaling redness of the skin
Some rare side effects include:
Pain or swelling in treated surfaces
Severe rash (for people with psoriasis only)
Intense dryness, itching, peeling or redness of the skin
Intense burning or tingling sensation of the skin
Generic Tazorac may cause local skin reactions (such as contact dermatitis) or irritation of the eyes and mucous membranes due to the presence of butyl-hydroxyanisole and butylhydroxytoluene.
Do not use the medicine under the compression bandages or in combination with other psoriasis medications for external use
Do not use this medicine if If you are pregnant or breastfeeding or if you plan to become pregnant
It is not suitable for children below 12 years of age