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Aziderm cream, Skinoren

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Aziderm 20% by Micro Labs (Skinoren) is used topically on the skin to treat mild or moderately severe acne and pimples. It is applied to relieve symptoms of various types of acne which may include redness, lesions, and bumps, etc. The medication is used for mild-to-moderate acne treatments.

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skinoren logoAziderm cream Skinoren tube box

Basic Information

Commercial name: Aziderm (generic Skinoren)
  • Active ingredient: Azelaic acid cream 20%
  • Volume: 15g
  • Strength: azelaic acid 20%
  • Form: cream
  • Usage: For external use only. A thin layer of cream on the affected area twice daily up to six months.
  • Duration: As recommended by the physician and depending on the severity of the disease.
  • Storage: Store below 25°C out of the reach of children.
  • Shelf-life: 2 years.
  • Manufacturer: Micro labs limited.
  • Origin: India
Aziderm cream Skinoren tube


Are you still troubles by acne?

Nowadays a medical science knows a lot about skin deaseases that affect face. Despite the fact that they do not pose a serious threat to health and life, nevertheless, such conitions greatly affect the aesthetics, attractiveness and self-esteem of a person.
Azelaic acid cream (Aziderm) is an effective anti-acne medication proven to be highly effective in mild and moderate cases. Aziderm prevents the formation of horny plugs, thereby reducing visible comedones (black and white dots),
inhibits the growth of bacteria invovled in inflammatory processes.

Acne vulgaristypes of rosacea with example

Aziderm - probably one of the best acne treatments!

Your doctor may prescribe Azelaic acid cream as a solution to your problem. Aziderm is a non steroidal cream with proven effect in acne vulgaris. It possesses a triple action mechanism and provides great treatment results.
An improvement in the condition of the skin and a decrease in the severity of the pathological process occurs after 2 to 4 weeks of regular use of the cream. Aziderm is mainly prescribed for women.


aziderm befor after

Why do you need to use Aziderm cream? 

1.Acts on the causes of acne
2.Does not cause dependence
3.Relives acne symptoms
4.Can be used during pregnancy and breastfeeding
5.Causes less dryness and irritation than some other products
aziderm woman

How to Use Aziderm cream

1. Before applying the cream, rinse the skin thoroughly with clean water and then dry, or use a mild cosmetic cleanser.  2. Do not use occlusive dressings. Hands should be washed after each application of the cream to the skin. 3. Apply a thin layer of cram on the affected skin 2 times a day (morning and evening), slightly
rubbing into the skin.
4. Avoid contact of Azelaic acid cream with mucous membranes of the nose and eyes. 5. Do not use after expiration date. Continue using cream even the results are not visible within the first 2-3 weeks. 

Aziderm treatment progress

acne vulgaris progressrosacea progress

Treatment progress with Aziderm cream

  • It is important that Aziderm is used regularly and prescribed during the entire treatment period.
  • The lenghth of treatment depends on the severity of the disease. Usualy good improvements are achieved within 4 weeks. If necessery the treatment can lasts up to 3 months.

Full satisfaction is guaranteed!!!

aziderm is skinoren

Skinoren and Aziderm are identical products made by two different manufacturers. They contain the same active ingredient Azelaic acid and are used for the same purposes - acne. Both products provide great results ance of mild and moderate severity.

  • Skinoren=Aziderm

  • Same active ingredients

  • Same additives

  • Same volume

  • Same indications

  • Same results for less money

aziderm azelaic acid cream feel free of acne

Aziderm cream brief description

Product name - Aziderm 20% by Micro Labs (Skinoren)

Qualitative and quantitative composition -

1g of Aziderm 20% by Micro Labs (Skinoren) contains 200 mg Azeliac Acid (20% w/w). 

Action mechanism:

In skin prone to acne, it reduces swelling and redness through its anti-inflammatory actions. It is used for the treatment of moderate to mild acne and pimples. The medicine operates by reducing the number of bacteria triggering acne on your skin and aiding to maintain the skin pores healthy. So, the number of skin bumps due to acne gets reduced. Moreover, it limits the keratin production of the skin. Keratin is a protein that is often associated with blockage of the skin pores, resulting in acne formation. Aziderm functions by reducing the number of bacteria that cause acne on the body and helping to keep the pores free and unblocked thus decreasing the number of pimples. The main component of the cream is azelaic acid that belongs to a group of drug class termed dicarboxylic acids. This cream can be regarded as the first line of defense against Rosacea and Acne vulgaris. It is not indicated for severe acne infection and problems. 

Indication

Aziderm (Skinoren / Azelaic acid cream) is indicated for the treatment of Rosacea and Acne vulgaris. It soothes the rosacea associated symptoms, which include pimples, flushing, and redness of the skin, etc.

The cream is used for the reduction of the symptoms linked to acne vulgaris as well. The common symptoms of acne vulgaris are skin bumps, tenderness, redness, blackheads, etc.

Mode of administration

Skinoren known as Aziderm is for external use only. Do not apply inside your mouth. Wash your hands before and after application. Make sure the skin is clean and dry. Apply the right amount of cream (a thin layer) to cover the affected area and rub lightly. It may take up to 4 weeks before you see the full effect of this medicine.

Contraindication

You should not use this medicine or ask your doctor before using it if you have the following conditions:

  • Herpes or fever blisters
  • You have the previous history of allergies to ingredients such as different preservatives, dyes, foods, medicines, azelaic acid, propylene glycol, and similar products.
  • In case you are planning a pregnancy or already pregnant
  • If you are breastfeeding

Special cautions and warnings - Contact your doctor or healthcare professional if your skin condition worsens or does not improve within the first 4 weeks. Tell your doctor if the medicine causes too much redness, dryness, or causes the skin to peel.

Drug interaction

There is no official drug interactions are known or expected. However, do not use any other skin products in the affected area without first checking with your doctor or healthcare professional. Give your doctor a list of all medications, herbs, over-the-counter medicines, or dietary supplements that you are taking. Also, inform him whether you smoke, drink alcohol, or use other abusive drugs. Some of these may interact with Aziderm.

Side effects :

Aziderm common side effects of the medicine include:

  • Allergic reactions such as skin rashes, itching or hives, swelling of the face, lips, or tongue
  • Lighter skin color in treated areas (in patients with dark skin)
  • Severe burning, itching, scabs, or inflammation of the treated areas

In some people the following side effects can be seen:

  • Dry Skin
  • Mild burning sensation, severe itching or tingling
  • Redness of the skin
  • Peeling of skin

In case of severe allergic reactions on rare occasions, symptoms like sudden and unexpected swelling of tongue, throat, face, and eyelids take place. People also suffer from difficulty in swallowing and breathing. These patients need immediate medical intervention and emergency care.

Interesting facts

  • Keep the cream out of the eyes, mouth, and other sensitive areas of the skin. If the cream comes into contact with these parts of the skin by accident, wash the affected area with plenty of water and contact your doctor if the irritation persists.
  • Do not place bandages, bandages, or dressings on the skin on which the medication was applied.
  • There have been no indications of habit-forming phenomena of this cream.
  • If you are using other topical medications, apply them at different times of the day.
  • Talk to your pediatrician about the use of this medicine in children, as special care may be needed.
  • You can use small amounts of water-based cosmetics while using this medicine. Apply makeup after the cream has dried.
  • There is no medical assessment of the period needed to show the action of this cream.
  • No clinical assessment is made of the length of time this drug is active. After the initial use or stopping the use of the medicine.

Aziderm cream real shots
Aziderm cream Skinoren tube box

Aziderm cream Skinoren tube boxAziderm cream Skinoren tube box
Aziderm cream Skinoren tube box

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Full Original Product Annotation

Aziderm cream / SkinorenFor the use of Registered Medical Practitioner or a Hospital or a Laboratory only.

Aziderm cream / Skinoren

Composition:

Aziderm 10% - Azelaic Acid 10% w/w

Benzoic Acid IP  0.2% w/w (as preservative) In a cream base.

Aziderm Azelaic Acid 20% w/w in a cream base.

Description: Azelaic Acid is a naturally occurring C9 dicarboxylic acid.

Structural Formula: HOOC-(CH2)7COOH

Chemical Name:

1,7- heptanedicarboxylic acid

Empirical Formula: C9H18O4

Molecular weight: 188.22

Pharmacodynamics:

Azelaic Acid in Acne: Topical application of 20% Azelaic Acid cream (Skinoren) caused marked reduction in the densities of cutaneous micro-coccaceae and intrafollicular Propionibacterium Sp., and decreased the free fatty acid content of skin surface lipids. Topical 20% Azelaic acid cream also showed an antikeratinising effect on acne affected skin which was related to decreased synthesis of filaggrin (keratin filament aggregating protein); hence a reduction in follicular hyperkeratosis may partly underlie the drug's antiacne action 1. Since Azelaic acid affects the cornification process of the epidermal cells, it exerts a therapeutically positive effect on the formation of comedones. Azelaic acid also inhibits the release of oxygen radical from neutrophilic granulocytes, and thus may have a clinically relevant anti inflammatory action in acne.

Azelaic acid in hyperpigmentation: Azelaic acid appears to act selectively on hyperactive and abnormal melanocytes, by competitively inhibiting tyrosinase, the key enzyme for melanogenesis. The anti­proliferative and cytotoxic actions of Azelaic acid may be due to reversible inhibition of variety of oxidoreductase enzymes like DNA polymerase and mitochondrial enzymes of the respiratory chain. Differences in cellular permeability and / or metabolic activity may account for the greater susceptibility of hyperactive and abnormal epidermal cells (keratinocytes and melanocytes) to the antiproliferative and depigmenting actions of Azelaic acid.

Pharmacokinetics: Following a single application of Aziderm to human skin in vitro, Azelaic acid penetrates into the stratum comeum (approximately 3 to 5% of the applied dose) and other viable skin layers (up to 10% of the dose is found in the epidermis and dermis). Negligible cutaneous metabolism occurs after topical application. Approximately 4% of the topically applied Azelaic acid is systemically absorbed. Azelaic add is mainly excreted unchanged in urine but undergoes some beta-oxidation to shorter chain dicarboxylic adds. After topical treatment of Aziderm in humans, plasma concentration and urinary excretion of Azelaic acid are not significantly different from baseline levels.

Indications: Aziderm / Skinoren is effective against hyperpigmentary disorders (such as melasma, post inflammatory melanoderma, Lentigo maligna) Aziderm is also effective in acne (comedonal and inflammatory acne)

Contra-indications: Hypersensitivity to Propylene glycol. Aziderm should not be used by pregnant, lactating women and in children below 12 years, as it has not been studied in these circumstances.

Warning: There have been isolated reports of hypopigmentation after use of Azelaic acid. Patients with dark complexion should be monitored for early signs of hypopigmentation.

Precautions: General: If sensitivity or severe irritation develops with use of Aziderm, treatment should be discontinued and appropriate therapy instituted.

Information to patients: Patients should be instructed to keep Aziderm away from mouth, eyes, and other mucous membranes. If Skinoren comes in contact with the eyes, then it should be thoroughly rinsed with copious amounts of water. Avoid the use of occlusive dressing or wrappings. Due to low pH of Azelaic acid, temporary skin irritation (pruritus, burning, or stinging) may occur when Aziderm is applied to broken or inflamed skin, usually at the start of treatment. However, this irritation commonly subsides if treatment is continued, if it continued, Aziderm should be applied only once-a-day, or the treatment should be stopped until these effects have subsided. If troublesome irritation persists, the patient should consult their physician.

Side effects: The most common adverse reactions occurring in approximately 1-5% of patients were pruritus, burning, stinging and tingling. Other adverse reactions such as erythema, dryness, rash, peeling, irritation, dermatitis, and contact dermatitis were reported in less than 1% of subjects. There is the potential for experiencing allergic reactions with use of Skinoren (Aziderm).

Dosage and administration: Before Aziderm is applied, the skin should be thoroughly cleaned with clear water or, if applicable a mild skin-cleansing agent. Astringent toiletries should generally be avoided. Aziderm cream should be gently rubbed into cleansed skin 2 to 3 minutes to ensure adequate penetration. The cream is to be applied on the affected areas of skin twice a day (morning and evening). As a guide a daily dose of 2g (1g Per application) will be sufficient. In the event of excessive irritation of the skin, the frequency of use of Aziderm should be reduced to once a day until the irritation ceases or the treatment should be temporarily interrupted. It is important to continue the use of Aziderm regularly over the entire period of treatment. The duration of use of Aziderm varies from person to person and depends on the severity of the acne/ hyperpigmentation. To obtain the best results, Aziderm / Skinoren should be used regularly over several months but not more than six months. Improvement in majority of patients with inflammatory lesions usually occurs within four weeks.

Storage: Store all drugs properly and keep them out of the reach of children. Store between 15°C-30°C (59°-86°F) Protect from freezing.

Usage and precautions:

  1. Avoid exposure to sunlight. To avoid becoming susceptible to sunburn, do not go out in the sunlight after applying the cream. Use any sunscreen lotion or ideally use an umbrella in such a case.
  2. Sometimes there may be an appearance of new acne pimples. This is due to the action of Azelaic acid on previously unseen lesions.
  3. There may be some discomfort or peeling during the early days of treatment. This is not experienced by everyone. This indicates that your skin is adjusting to the medication.
  4. Continue the prescription until your physician instructs you. Be patient to get good results with Azelaic acid treatment.
  5. Local skin irritation (itching & burning) may occur, but regress in course of time.
  6. Avoid cosmetics that contain high concentration of alcohol or lime.

This preparation should be used strictly under medical supervision only. 

Presentation:

Aziderm-10% 15g tubes

Aziderm- 15g tubes

References:

Andrew Fitton and Karen L Goa: Drugs: 1991; 780-798. Akamatsu H et al; Arch Dermatol Res; 1991; 283; 162-166 Nazzaro-Porro M et al; J Invest Dermatol: 1978a;71;205-208

Made In India by:

MICRO LABS LIMITED

92. SIPCOT Industnal Complex.

HOSUR-635 126 (T.N.)

® Rogd. Trade Mark

 

 

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