• Candiderma (Triderm generic)
  • Candiderma (Triderm generic)
  • Candiderma (Triderm generic)
  • Candiderma (Triderm generic)
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Candiderma (Triderm generic)


Candiderma is a combination medicine used in the cutaneous application in dermatology. Candiderma cream has anti-inflammatory, antiallergenic, antipruritic, antimycotic and antibacterial effects

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Product name - Generic Triderm cream (Candiderma) by Glenmark

Qualitative and quantitative composition - Generic Triderm cream (Candiderma) by Glenmark is a combination of three compounds - Betamethasone, Clotrimazole, and Gentamicin. 1 g of Triderm cream contains: betamethasone (betamethasone dipropionate) 500 mcg (0.05%), clotrimazole 10 mg and gentamicin (gentamicin sulfate) 1 mg.

Action mechanism:

Candiderma cream is a combination preparation for dermatological use. After the application, it has an anti-inflammatory, antiallergenic and antipruritic effect associated with betamethasone, an antimycotic effect with clotrimazole and antibacterial caused by gentamicin. 

Betamethasone dipropionate is a synthetic corticosteroid (SCS). It has a powerful vasoconstrictor and anti-inflammatory effect. Bethametasome is characterized by a rapid and prolonged anti-inflammatory effect. 

Clotrimazole has an antimycotic effect (inhibits the synthesis of ergosterol in the cell membrane of molds).

It is used to reduce the inflammatory manifestations of dermatoses complicated by secondary infections caused by sensitive microorganisms and molds: mycosis, candidiasis, multicolored shingles, eczema, athlete's foot, tinea versicolor.

Clotrimazole is effective in the treatment of dermatomycoses such as Tinea redis, Tinea ciuris, Tinea corporis, caused by Trichophyton rlibrum, Trichophyton mentagrophyles, Epidermophyton floccosum, and Microsporum canis; candidiasis caused by Sandida albicans; Tinea versicolar (pityriasis), caused by Malassezia furtur (Pitysporum obiculare). 

Gentamicin is the broad-spectrum antibiotic that belongs to the group of aminoglycoside antibiotics. It has a bactericidal effect and is highly effective in the local treatment of primary and secondary bacterial infections of the skin. Gentamicin is effective against Streptococcus. (Beta - and alpha-hemolytic group A streptococcus), Staphylococcus aureus (coagulase-positive and coagulase-negative and some penicillinase-producing stains) and Gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae.

Indication - All of the three main ingredients in the cream contribute to the decrease of inflammation and some bacterial infections in the skin. 

Therefore Triderm is used to:

  • Inflammation caused by dermatosis

  • Athlete's foot 

  • Tinea curis:  An infection caused by fungi in the genitals, buttocks, and inner part of the thighs. It is characterized by a red rash that causes itching.

  • Candidiasis:  Infection caused by the fungus candida. It occurs mostly in the mucous membranes and on the skin.

  • Tinea versicolor: It is an infectious disease that produces discolored spots on the skin.

  • Various forms of bacterially infected eczema

Mode of administration - Triderm cream 15g can be used for the treatment of adults and children over 2 years. A thin layer of Tridem cream is applied to the damaged area 2 times a day - morning and evening. The duration of treatment depends on the clinical assessment and the severity of the disease.


The use of Triderm cream is contraindicated in case of: 

  • Varicella

  • Skin reactions after vaccination 

  • Hypersensitivity to any of the ingredients of the medication

  • Cutaneous manifestations of syphilis 

  • Children under 2 years old

Special cautions and warnings:

Systemic absorption of corticosteroids, including betamethasone and topical application of gentamicin, would be more important if treatment was performed over large areas of the body or if occlusive clothing is used. 

Some side effects occur regularly with the use of systemic glucocorticoids and the local application of glucocorticosteroids such as suppression of adrenal cortex function, especially in children. The prolonged local use of antibiotics can sometimes lead to the proliferation of a resistant microflora. 

Do not apply Triderm cream on open wounds and burns. It is not recommended to use Triderm for the treatment of diaper rash. Triderm is not intended for ophthalmic use. The safety of corticosteroids in pregnant women has not been studied. Thus, the use of Tridem during pregnancy should be avoided.

When ingested, this drug can be dangerous. If anyone has overdose issues and has severe symptoms, such as breathing problems, contact emergency medical service immediately.

Drug interaction:

No specific drug interaction is known with this cream when applied topically. Before applying Triderm, be sure to tell your doctor if you are taking any prescription or over-the-counter medications. Be sure to inform your doctor if you are using oral corticosteroids and the use of oral antibiotics and oral antimycotics.

Side effects

Candiderma side effects of Triderm include allergic contact dermatitis, burning sensation, dryness, exudative erythema, folliculitis, hypertrichosis, hypopigmentation, irritation, itching, local edema, paresthesia, perioral dermatitis, rash, steroid acne, and urticaria.

If the occlusive bandage is used there may be laceration of the skin, secondary infection, skin atrophy, streak, miliaria.

Interesting facts

  • If not absolutely necessary, this drug is not advised to be used in breastfeeding mothers.

  • Before using Triderm cream, the physician must evaluate the benefits and risks especially for pregnant and lactating women as well as those planning a baby.

  • There have been no indications of habit-forming phenomena with this medicine.

  • There is no established interaction of this drug with alcohol. You must consult your physician before consuming alcohol.

  • There is no scientific indication of any time frame for this drug remaining active or effective on the skin.

  • It is not medically known how long this drug needs to show its effect.

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